Characterizing the reproduction number of epidemics with early subexponential growth dynamics

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Characterizing the reproduction number of epidemics with early subexponential growth dynamics.

Early estimates of the transmission potential of emerging and re-emerging infections are increasingly used to inform public health authorities on the level of risk posed by outbreaks. Existing methods to estimate the reproduction number generally assume exponential growth in case incidence in the first few disease generations, before susceptible depletion sets in. In reality, outbreaks can disp...

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The basic reproduction number, R(0), a summary measure of the transmission potential of an infectious disease, is estimated from early epidemic growth rate, but a likelihood-based method for the estimation has yet to be developed. The present study corrects the concept of the actual reproduction number, offering a simple framework for estimating R(0) without assuming exponential growth of cases...

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ژورنال

عنوان ژورنال: Journal of The Royal Society Interface

سال: 2016

ISSN: 1742-5689,1742-5662

DOI: 10.1098/rsif.2016.0659